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NESG statistics NESG (complete history) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   23,038 34,956 17,431 Expression tested   21,584 31,831 16,239 Expressed (E > 0)   16,374 22,108 12,846 Expressed-Soluble (S > 0)   12,150 15,371 10,200 Expressed-Soluble (ES >= 9)   9,705 12,094 8,241 Fermented   7,056 8,958 6,229 Purified (>= 0.5 mg yield)   4,656 5,567 4,076 HSQC spectra recorded   2,493 3,189 2,233 "Good" HSQC spectra   1,305 1,648 1,186 Crystal hit   1,277 1,424 1,176 X-Ray structures   529 532 520 568 NMR structures   438 440 432 458 41 Total structures   926 939 904 1,026 [activity table created 2012-02-04] NESG (PSI-1) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   5,514 7,692 5,345 Expression tested   4,684 5,971 4,562 Expressed (E > 0)   3,315 3,601 3,259 Expressed-Soluble (S > 0)   2,519 2,718 2,495 Expressed-Soluble (ES >= 9)   2,019 2,144 2,004 Fermented   2,404 3,067 2,367 Purified (>= 0.5 mg yield)   1,096 1,130 1,093 HSQC spectra recorded   794 1,099 793 "Good" HSQC spectra   347 488 346 Crystal hit   146 146 146 X-Ray structures   105 105 105 108 NMR structures   80 80 80 83 2 Total structures   183 183 183 191 [activity table created 2012-02-04] NESG (PSI-2) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   14,750 20,908 10,515 Expression tested   14,460 20,273 10,302 Expressed (E > 0)   10,899 14,391 8,204 Expressed-Soluble (S > 0)   8,240 10,346 6,704 Expressed-Soluble (ES >= 9)   6,540 8,101 5,379 Fermented   4,217 5,004 3,602 Purified (>= 0.5 mg yield)   3,213 3,771 2,751 HSQC spectra recorded   1,439 1,697 1,239 "Good" HSQC spectra   811 955 714 Crystal hit   1,033 1,147 941 X-Ray structures   371 374 365 398 NMR structures   300 301 296 311 31 Total structures   640 650 623 709 [activity table created 2012-02-04] NESG (PSI-Biology) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   3,200 6,436 2,297 Expression tested   3,389 6,387 2,499 Expressed (E > 0)   2,879 4,804 2,214 Expressed-Soluble (S > 0)   2,062 2,981 1,725 Expressed-Soluble (ES >= 9)   1,709 2,421 1,455 Fermented   894 1,280 760 Purified (>= 0.5 mg yield)   726 1,010 636 HSQC spectra recorded   362 480 328 "Good" HSQC spectra   200 253 188 Crystal hit   128 146 126 X-Ray structures   58 58 57 62 NMR structures   64 64 63 64 4 Total structures   118 119 116 126 [activity table created 2012-02-04] Human proteins Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   4,988 9,698 3,426 Expression tested   4,592 8,533 3,177 Expressed (E > 0)   3,574 6,038 2,567 Expressed-Soluble (S > 0)   2,389 3,590 1,861 Expressed-Soluble (ES >= 9)   1,891 2,754 1,505 Fermented   1,026 1,461 788 Purified (>= 0.5 mg yield)   727 1,047 562 HSQC spectra recorded   373 515 303 "Good" HSQC spectra   202 264 173 Crystal hit   128 148 108 X-Ray structures   34 34 33 36 NMR structures   62 62 59 63 8 Total structures   88 90 83 99 [attrition table created 2012-02-04] Eukaryotic proteins Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   6,069 12,095 4,393 Expression tested   5,387 10,111 3,875 Expressed (E > 0)   4,079 6,876 3,009 Expressed-Soluble (S > 0)   2,728 4,099 2,175 Expressed-Soluble (ES >= 9)   2,129 3,118 1,728 Fermented   1,496 2,261 1,249 Purified (>= 0.5 mg yield)   797 1,153 628 HSQC spectra recorded   561 861 488 "Good" HSQC spectra   265 374 234 Crystal hit   135 155 115 X-Ray structures   40 40 39 45 NMR structures   85 85 82 87 8 Total structures   117 119 112 132 [attrition table created 2012-02-04] Prokaryotic proteins Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   16,970 22,862 13,040 Expression tested   16,206 21,515 12,372 Expressed (E > 0)   12,301 15,238 9,841 Expressed-Soluble (S > 0)   9,428 11,278 8,029 Expressed-Soluble (ES >= 9)   7,582 8,982 6,517 Fermented   5,565 6,670 4,984 Purified (>= 0.5 mg yield)   3,869 4,427 3,454 HSQC spectra recorded   1,932 2,329 1,745 "Good" HSQC spectra   1,040 1,275 952 Crystal hit   1,144 1,271 1,063 X-Ray structures   493 496 485 525 NMR structures   353 355 350 371 33 Total structures   813 824 796 896 [attrition table created 2012-02-04] CRSH Production stage NESG targets distinct constructs UniProt ids depositions cloned   82 142 82 Expression tested   81 140 81 Expressed (E > 0)   67 104 67 Expressed-Soluble (S > 0)   59 89 59 Expressed-Soluble (ES >= 9)   50 76 50 Fermented   20 28 20 Purified (>= 0.5 mg yield)   19 26 19 HSQC spectra recorded   13 20 13 "Good" HSQC spectra   8 12 8 Crystal hit   2 3 2 X-Ray structures   1 1 1 1 NMR structures   0 0 0 0 Total structures   1 1 1 1 [attrition table created 2012-02-04] PSI-2 BIG domains assigned to NESG Production stage NESG targets distinct constructs UniProt ids depositions cloned   0 0 0 Expression tested   0 0 0 Expressed (E > 0)   0 0 0 Expressed-Soluble (S > 0)   0 0 0 Expressed-Soluble (ES >= 9)   0 0 0 Fermented   0 0 0 Purified (>= 0.5 mg yield)   0 0 0 HSQC spectra recorded   0 0 0 "Good" HSQC spectra   0 0 0 Crystal hit   0 0 0 X-Ray structures   0 0 0 0 NMR structures   0 0 0 0 Total structures   0 0 0 0 [attrition table created 2012-02-04] PSI-2 BIG domains Production stage NESG targets distinct constructs UniProt ids depositions cloned   0 0 0 Expression tested   0 0 0 Expressed (E > 0)   0 0 0 Expressed-Soluble (S > 0)   0 0 0 Expressed-Soluble (ES >= 9)   0 0 0 Fermented   0 0 0 Purified (>= 0.5 mg yield)   0 0 0 HSQC spectra recorded   0 0 0 "Good" HSQC spectra   0 0 0 Crystal hit   0 0 0 X-Ray structures   0 0 0 0 NMR structures   0 0 0 0 Total structures   0 0 0 0 [attrition table created 2012-02-04] Ubiquitin-like domains Production stage NESG targets distinct constructs UniProt ids depositions cloned   5 5 5 Expression tested   5 5 5 Expressed (E > 0)   4 4 4 Expressed-Soluble (S > 0)   2 2 2 Expressed-Soluble (ES >= 9)   2 2 2 Fermented   4 4 4 Purified (>= 0.5 mg yield)   1 1 1 HSQC spectra recorded   1 1 1 "Good" HSQC spectra   1 1 1 Crystal hit   0 0 0 X-Ray structures   0 0 0 0 NMR structures   3 3 3 3 Total structures   3 3 3 3 [attrition table created 2012-02-04] Human Ubiquitin-like domains Production stage NESG targets distinct constructs UniProt ids depositions cloned   0 0 0 Expression tested   0 0 0 Expressed (E > 0)   0 0 0 Expressed-Soluble (S > 0)   0 0 0 Expressed-Soluble (ES >= 9)   0 0 0 Fermented   0 0 0 Purified (>= 0.5 mg yield)   0 0 0 HSQC spectra recorded   0 0 0 "Good" HSQC spectra   0 0 0 Crystal hit   0 0 0 X-Ray structures   0 0 0 0 NMR structures   0 0 0 0 Total structures   0 0 0 0 [attrition table created 2012-02-04] PSI-Biology community outreach Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   396 695 320 Expression tested   381 659 316 Expressed (E > 0)   323 521 270 Expressed-Soluble (S > 0)   276 424 243 Expressed-Soluble (ES >= 9)   247 355 222 Fermented   248 334 231 Purified (>= 0.5 mg yield)   211 278 197 HSQC spectra recorded   87 102 80 "Good" HSQC spectra   51 62 47 Crystal hit   88 97 86 X-Ray structures   36 36 35 39 NMR structures   22 22 22 22 2 Total structures   56 57 55 61 [attrition table created 2012-02-04] D. Baker outreach targets Production stage NESG targets distinct constructs UniProt ids depositions cloned   118 132 117 Expression tested   115 128 115 Expressed (E > 0)   99 109 99 Expressed-Soluble (S > 0)   94 103 94 Expressed-Soluble (ES >= 9)   91 100 91 Fermented   99 107 99 Purified (>= 0.5 mg yield)   86 93 86 HSQC spectra recorded   35 35 35 "Good" HSQC spectra   18 18 18 Crystal hit   36 36 36 X-Ray structures   11 11 11 12 NMR structures   7 7 7 7 Total structures   18 18 18 19 [attrition table created 2012-02-04] HCPIN (Human Cancer Interaction Networks) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   2,462 6,032 1,240 Expression tested   2,202 5,091 1,107 Expressed (E > 0)   1,783 3,609 998 Expressed-Soluble (S > 0)   1,209 2,146 774 Expressed-Soluble (ES >= 9)   965 1,648 642 Fermented   620 973 416 Purified (>= 0.5 mg yield)   476 734 335 HSQC spectra recorded   284 411 221 "Good" HSQC spectra   165 219 137 Crystal hit   108 126 88 X-Ray structures   24 24 23 26 NMR structures   47 47 45 48 6 Total structures   65 67 61 74 [attrition table created 2012-02-04] Mitochondrial Proteome Partnership Production stage NESG targets distinct constructs UniProt ids depositions cloned   384 948 189 Expression tested   381 941 187 Expressed (E > 0)   294 648 156 Expressed-Soluble (S > 0)   144 256 93 Expressed-Soluble (ES >= 9)   109 191 72 Fermented   65 112 52 Purified (>= 0.5 mg yield)   52 86 41 HSQC spectra recorded   21 38 18 "Good" HSQC spectra   10 16 9 Crystal hit   8 9 8 X-Ray structures   1 1 1 1 NMR structures   2 2 2 2 Total structures   3 3 3 3 [attrition table created 2012-02-04] Mitochondrial Proteome Partnership - nominated targets Production stage NESG targets distinct constructs UniProt ids depositions cloned   171 450 76 Expression tested   168 443 74 Expressed (E > 0)   147 356 71 Expressed-Soluble (S > 0)   81 158 49 Expressed-Soluble (ES >= 9)   55 106 35 Fermented   29 62 22 Purified (>= 0.5 mg yield)   20 41 15 HSQC spectra recorded   9 22 7 "Good" HSQC spectra   6 12 5 Crystal hit   2 3 2 X-Ray structures   0 0 0 0 NMR structures   1 1 1 1 Total structures   1 1 1 1 [attrition table created 2012-02-04] Chaperone-Enabled Studies of Epigenetic Regulation Enzymes Production stage NESG targets distinct constructs UniProt ids depositions cloned   179 464 107 Expression tested   172 442 101 Expressed (E > 0)   153 368 93 Expressed-Soluble (S > 0)   91 155 69 Expressed-Soluble (ES >= 9)   76 118 61 Fermented   41 62 36 Purified (>= 0.5 mg yield)   31 42 29 HSQC spectra recorded   7 11 6 "Good" HSQC spectra   7 11 6 Crystal hit   3 3 3 X-Ray structures   0 0 0 0 NMR structures   2 2 2 2 Total structures   2 2 2 2 [attrition table created 2012-02-04] Human transcription factors Production stage NESG targets distinct constructs UniProt ids HUGO ids cloned   1,714 2,756 1,377 1,372 Expressed (E > 0)   1,469 2,146 1,214 1,211 Expressed-Soluble (S > 0)   1,123 1,530 953 952 Expressed-Soluble (ES >= 9)   904 1,214 779 779 Purified (>= 0.5 mg yield)   166 252 127 130 [attrition table created 2012-02-04] Bet v1-like super family Production stage NESG targets distinct constructs UniProt ids depositions cloned   0 0 0 Expression tested   0 0 0 Expressed (E > 0)   0 0 0 Expressed-Soluble (S > 0)   0 0 0 Expressed-Soluble (ES >= 9)   0 0 0 Fermented   0 0 0 Purified (>= 0.5 mg yield)   0 0 0 HSQC spectra recorded   0 0 0 "Good" HSQC spectra   0 0 0 Crystal hit   0 0 0 X-Ray structures   0 0 0 0 NMR structures   0 0 0 0 Total structures   0 0 0 0 [attrition table created 2012-02-04] Philips Enzyme Natural Products project (closed) Production stage NESG targets distinct constructs UniProt ids depositions cloned   28 71 26 Expression tested   28 71 26 Expressed (E > 0)   26 62 24 Expressed-Soluble (S > 0)   15 29 13 Expressed-Soluble (ES >= 9)   14 26 12 Fermented   11 12 11 Purified (>= 0.5 mg yield)   11 12 11 HSQC spectra recorded   4 4 4 "Good" HSQC spectra   3 3 3 Crystal hit   3 3 3 X-Ray structures   0 0 0 0 NMR structures   0 0 0 0 Total structures   0 0 0 0 [attrition table created 2012-02-04]